First, researchers monitored them sleeping at least eight hours a night for six weeks. "This work emphasizes the importance of adults consistently sleeping seven to eight hours a day to help prevent inflammation and disease, especially for those with underlying medical conditions."Ī team of investigators analyzed 14 healthy adults who regularly sleep eight hours a night. This is important because it is yet another key observation that sleep reduces inflammation and, conversely, that sleep interruption increases inflammation," says lead author Filip Swirski, Ph.D., Director of the Cardiovascular Research Institute at Icahn Mount Sinai. It shows that in humans and mice, disrupted sleep has a profound influence on the programming of immune cells and rate of their production, causing them to lose their protective effects and actually make infections worse-and these changes are long-lasting. "This study begins to identify the biological mechanisms that link sleep and immunological health over the long-term. The study is also the first to show that catching up on sleep doesn't reverse the effects of sleep disruption. Immune cells fight infection, but if the number of these cells gets too high, they overreact and cause inflammation.
The research, published September 21 in the Journal of Experimental Medicine, is the first to show that sleep alters the structure of DNA inside the immune stem cells that produce white blood cells-also known as immune cells-and this can have a long-lasting impact on inflammation and contribute to inflammatory diseases.
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